No Clue… No Signs… Unpredictable and Bizarre: The Burden of Impaired Awareness of Hypoglycemia Among Patients on Hemodialysis—Findings of a Sequential Explanatory Mixed-Methods Study from South India


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DOI:

https://doi.org/10.59455/jomes.62

Keywords:

impaired awareness of hypoglycemia, hemodialysis, mixed-methods, Clark’s score

Abstract

Hipoglisemi farkındalığının bozulması (IAH), kan şekeri seviyelerinde önemli bir düşüşü algılayamama veya hissedememe durumunu ifade eder. Bu açıklayıcı ardışık karma yöntemli çalışma, hemodiyaliz uygulanan hastalarda IAH prevalansını belirlemeyi ve etkilenen hastaların ve yakınlarının deneyimlerini araştırmayı amaçlamıştır. Nicel aşamada, 86 hemodiyaliz hastasında Clark anketi kullanılarak IAH değerlendirilmiş, ardından 16 katılımcıyla yapılan görüşmeleri içeren derinlemesine nitel bir aşama gerçekleştirilmiştir. Nicel veriler tanımlayıcı istatistikler ve ilişki testleri kullanılarak analiz edilirken, nitel veriler tematik analiz yoluyla incelenmiştir. Bulgular, IAH'yi düşündüren ≥4'lük bir Clark puanının ortalama 5,01 (±1,2) puan verdiğini, katılımcıların %28,7'sinin (±2,7) ​​şiddetli IAH yaşadığını ve %40,4'ünün hipoglisemi korkusu bildirdiğini göstermiştir. Niteliksel analiz üç ana temayı ortaya çıkardı: farkındalığın büyük önemi, hipoglisemi farkındalığının (IAH) deneyimleri ve günlük yaşam üzerindeki etkisi ile IAH'yi ele almak için çözümler ve stratejiler. Genel olarak, sonuçlar hemodiyaliz popülasyonunda hipoglisemi farkındalığının önemli ölçüde yüksek oranda olduğunu göstermekte ve bu yüksek riskli grup için kapsamlı ve bireyselleştirilmiş klinik stratejiler geliştirmede sağlık profesyonellerini desteklemek amacıyla IAH düzeylerinin belirlenmesinin önemini vurgulamaktadır.

References

Ang, L. C., Bee, Y. M., Goh, S.-Y., & Teh, M. M. (2023). New insights into the currently available questionnaire for assessing impaired awareness of hypoglycaemia (IAH) among insulin-treated type 2 diabetes- A key risk factor for hypoglycaemia. Diabetes Epidemiology and Management, 10, 100136. https://doi.org/10.1016/j.deman.2023.100136 DOI: https://doi.org/10.1016/j.deman.2023.100136

Bossola, M., Hedayati, S. S., Brys, A. D. H., & Gregg, L. P. (2023). Fatigue in Patients Receiving Maintenance Hemodialysis: A Review. American Journal of Kidney Diseases, 82(4), 464–480. https://doi.org/10.1053/j.ajkd.2023.02.008 DOI: https://doi.org/10.1053/j.ajkd.2023.02.008

Chu, Y.-W., Lin, H.-M., Wang, J.-J., Weng, S.-F., Lin, C.-C., & Chien, C.-C. (2017). Epidemiology and outcomes of hypoglycemia in patients with advanced diabetic kidney disease on dialysis: A national cohort study. PLOS ONE, 12(3), e0174601. https://doi.org/10.1371/journal.pone.0174601 DOI: https://doi.org/10.1371/journal.pone.0174601

Clarke, W. L., Cox, D. J., Gonder-Frederick, L. A., Julian, D., Schlundt, D., & Polonsky, W. (1995). Reduced awareness of hypoglycemia in adults with IDDM: A prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care, 18(4), 517–522. https://doi.org/10.2337/diacare.18.4.517 DOI: https://doi.org/10.2337/diacare.18.4.517

Creswell, J. W. (2014). Research Design Qualitative,Quantitative and mixed methods (V. Knight, J. Young, K. Koscielak, B. Bauhaus, & M. Markanich, Eds.). SAGE Publications, Inc.

Elliott, J., & Heller, S. (2011). Hypoglycaemia unawareness. Practical Diabetes International, 28(5), 227–232. https://doi.org/10.1002/pdi.1600 DOI: https://doi.org/10.1002/pdi.1600

Farrell, C. M., & McCrimmon, R. J. (2021). Clinical approaches to treat impaired awareness of hypoglycaemia. Therapeutic Advances in Endocrinology and Metabolism, 12, 20420188211000248. https://doi.org/10.1177/20420188211000248 DOI: https://doi.org/10.1177/20420188211000248

Fetters, M. D., Curry, L. A., & Creswell, J. W. (2013). Achieving integration in mixed methods designs—Principles and practices. Health Services Research, 48(6 PART2), 2134–2156. https://doi.org/10.1111/1475-6773.12117 DOI: https://doi.org/10.1111/1475-6773.12117

Gahatraj, J., Visudtibhan, P. J., Junda, T., & Butsing, N. (2023). Predicting factors of health-related quality of life among end-stage renal disease patients receiving hemodialysis at a tertiary level hospital in Nepal. Journal of Health Research, 38(2). https://doi.org/10.56808/2586-940X.1070 DOI: https://doi.org/10.56808/2586-940X.1070

Habte-Asres, H. H., Jiang, Y., Rosenthal, M., & Wheeler, D. C. (2024). Burden of impaired awareness of hypoglycemia in people with diabetes undergoing hemodialysis. BMJ Open Diabetes Research and Care, 12(1), e003730. https://doi.org/10.1136/bmjdrc-2023-003730 DOI: https://doi.org/10.1136/bmjdrc-2023-003730

Hayashi, A., Shimizu, N., Suzuki, A., Matoba, K., Momozono, A., Masaki, T., Ogawa, A., Moriguchi, I., Takano, K., Kobayashi, N., & Shichiri, M. (2021). Hemodialysis-Related Glycemic Disarray Proven by Continuous Glucose Monitoring; Glycemic Markers and Hypoglycemia. Diabetes Care, 44(7). https://doi.org/10.2337/dc21-0269 DOI: https://doi.org/10.2337/dc21-0269

Hayashino, Y., Fukuhara, S., Akiba, T., Akizawa, T., Asano, Y., Saito, A., Bragg-Gresham, J. L., Ramirez, S. P. B., Port, F. K., & Kurokawa, K. (2007). Diabetes, glycaemic control and mortality risk in patients on haemodialysis: The Japan Dialysis Outcomes and Practice Pattern Study. Diabetologia, 50(6), 1170–1177. https://doi.org/10.1007/s00125-007-0650-z DOI: https://doi.org/10.1007/s00125-007-0650-z

Jung, H. S., Kim, H. I. I., Kim, M. J., Yoon, J. W., Ahn, H. Y., Cho, Y. M., Oh, K. H., Joo, K. W., Lee, J. G., Kim, S. Y., & Park, K. S. (2010). Analysis of hemodialysis-associated hypoglycemia in patients with type 2 diabetes using a continuous glucose monitoring system. Diabetes Technology and Therapeutics, 12(10), 801–807. https://doi.org/10.1089/dia.2010.0067 DOI: https://doi.org/10.1089/dia.2010.0067

Kiger, M. E., & Varpio, L. (2020). Thematic analysis of qualitative data: AMEE Guide No. 131. Medical Teacher, 42(8), 846–854. https://doi.org/10.1080/0142159X.2020.1755030 DOI: https://doi.org/10.1080/0142159X.2020.1755030

Lin, Y. K., Fisher, S. J., & Pop-Busui, R. (2020). Hypoglycemia unawareness and autonomic dysfunction in diabetes: Lessons learned and roles of diabetes technologies. Journal of Diabetes Investigation, 11(6), 1388–1402. https://doi.org/10.1111/JDI.13290 DOI: https://doi.org/10.1111/jdi.13290

Martín-Timón, I. (2015). Mechanisms of hypoglycemia unawareness and implications in diabetic patients. World Journal of Diabetes, 6(7), 912. https://doi.org/10.4239/wjd.v6.i7.912 DOI: https://doi.org/10.4239/wjd.v6.i7.912

McCoy, R. G., Lipska, K. J., Van Houten, H. K., & Shah, N. D. (2020). Association of Cumulative Multimorbidity, Glycemic Control, and Medication Use With Hypoglycemia-Related Emergency Department Visits and Hospitalizations Among Adults With Diabetes. JAMA Network Open, 3(1), e1919099. https://doi.org/10.1001/jamanetworkopen.2019.19099 DOI: https://doi.org/10.1001/jamanetworkopen.2019.19099

Moen, M. F., Zhan, M., Hsu, V. D., Walker, L. D., Einhorn, L. M., Seliger, S. L., & Fink, J. C. (2009). Frequency of hypoglycemia and its significance in chronic kidney disease. Clinical Journal of the American Society of Nephrology. https://doi.org/10.2215/CJN.00800209 DOI: https://doi.org/10.2215/CJN.00800209

Ng, M. S. N., Chan, D. N. S., Cheng, Q., Miaskowski, C., & So, W. K. W. (2021). Association between Financial Hardship and Symptom Burden in Patients Receiving Maintenance Dialysis: A Systematic Review. International Journal of Environmental Research and Public Health, 18(18), Article 18. https://doi.org/10.3390/ijerph18189541 DOI: https://doi.org/10.3390/ijerph18189541

O’cathain, A., Murphy, E., & Nicholl, J. (2008). The Quality of Mixed Methods Studies in Health Services Research. Journal of Health Services Research & Policy, 13(2), 92–98. https://doi.org/10.1258/jhsrp.2007.007074 DOI: https://doi.org/10.1258/jhsrp.2007.007074

Onwuegbuzie, A. J., & Collins, K. M. T. (2007). A typology of mixed methods sampling designs in social science research. The Qualitative Report, 12(2), 474–498.

Pedersen-bjergaard, T., Windows, M., Prevalence, R., & The, I. a H. (2007). An Evaluation of Methods of Assessing. 1868–1870. https://doi.org/10.2337/dc06-2556.Abbreviations

Rankin, D., Elliott, J., Heller, S., Amiel, S., Rogers, H., Dezoysa, N., & Lawton, J. (2014). Experiences of hypoglycaemia unawareness amongst people with Type 1 diabetes: A qualitative investigation. Chronic Illness, 10(3), 180–191. https://doi.org/10.1177/1742395313513911 DOI: https://doi.org/10.1177/1742395313513911

Sahathevan, S., Khor, B.-H., Ng, H.-M., Abdul Gafor, A. H., Mat Daud, Z. A., Mafra, D., & Karupaiah, T. (2020). Understanding Development of Malnutrition in Hemodialysis Patients: A Narrative Review. Nutrients, 12(10), 3147. https://doi.org/10.3390/nu12103147 DOI: https://doi.org/10.3390/nu12103147

Samya, V., Shriraam, V., Jasmine, A., Akila, G. V., Anitha Rani, M., Durai, V., Gayathri, T., & Mahadevan, S. (2019). Prevalence of Hypoglycemia Among Patients With Type 2 Diabetes Mellitus in a Rural Health Center in South India. Journal of Primary Care & Community Health, 10, 2150132719880638. https://doi.org/10.1177/2150132719880638 DOI: https://doi.org/10.1177/2150132719880638

Shafiee, G., Mohajeri-Tehrani, M., Pajouhi, M., & Larijani, B. (2012). The importance of hypoglycemia in diabetic patients. Journal of Diabetes & Metabolic Disorders, 11(1), 17. https://doi.org/10.1186/2251-6581-11-17 DOI: https://doi.org/10.1186/2251-6581-11-17

Williams, S. A., Pollack, M. F., & DiBonaventura, M. (2011). Effects of hypoglycemia on health-related quality of life, treatment satisfaction and healthcare resource utilization in patients with type 2 diabetes mellitus. Diabetes Research and Clinical Practice, 91(3), 363–370. https://doi.org/10.1016/j.diabres.2010.12.027 DOI: https://doi.org/10.1016/j.diabres.2010.12.027

Younas, A., Pedersen, M., & Durante, A. (2020). Characteristics of joint displays illustrating data integration in mixed-methods nursing studies. Journal of Advanced Nursing, 76(2), 676–686. https://doi.org/10.1111/jan.14264 DOI: https://doi.org/10.1111/jan.14264

Yu, X., Fan, M., Zhao, X., Ding, Y., Liu, X., Yang, S., & Zhang, X. (2023). Prevalence of impaired awareness of hypoglycaemia in people with diabetes mellitus: A systematic review and meta-analysis from 21 countries and regions. Diabetic Medicine, 40(9), e15129. https://doi.org/10.1111/dme.15129 DOI: https://doi.org/10.1111/dme.15129

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Published

2025-12-26

How to Cite

C K, R., S Kumar, A. ., & Gracious, N. . (2025). No Clue… No Signs… Unpredictable and Bizarre: The Burden of Impaired Awareness of Hypoglycemia Among Patients on Hemodialysis—Findings of a Sequential Explanatory Mixed-Methods Study from South India. Journal of Mixed Methods Studies, (12), 43–58. https://doi.org/10.59455/jomes.62